منابع مشابه
Rho GTPases
Cell migration is a complex, dynamic process that involves continuous remodeling of the cellular architecture, which is needed in order for the cell to move and adapt to changes in the surrounding environment. It requires rapidly activated and spatiotemporally regulated signaling networks that enable cellular responses to external cues. Rho-family GTPases are key components of these signaling n...
متن کاملRho Gtpases
The composition of the extracellular matrix (ECM) surrounding cells is key to their behavior: it modulates their ability to proliferate, differentiate, and migrate (Giancotti and Ruoslahti, 1999). ECM components can signal directly to cells through transmembrane receptors such as inte-grins, and can also present soluble cytokines and growth factors to cells. The morphology of cells varies great...
متن کاملRho GTPases
In his review of the Ras family in 1988, Pierre Chardin speculated that an obscure subfamily of the Ras superfamily, which at that time was only known in yeast, would be conserved in mammals. He was of course right, and today the number of labs and the amount of effort being expended to understand the vast network of Rho-family signaling is enormous. Given their fundamental role in normal and d...
متن کاملRho family GTPases.
Rho GTPases comprise a family of molecular switches that control signal transduction pathways in eukaryotic cells. A conformational change induced upon binding GTP promotes an interaction with target (effector) proteins to generate a cellular response. A highly conserved function of Rho GTPases from yeast to humans is to control the actin cytoskeleton, although, in addition, they promote a wide...
متن کاملSnapShot: Rho Family GTPases
Rho RhoA (RHOA) Plasma membrane (PM) and cytosol/ geranylgeranylation (GG), phosphorylation (PH), ubiquitination (Ub)
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2000
ISSN: 0021-9525,1540-8140
DOI: 10.1083/jcb.150.4.f107